Journal article
Natural product biosynthesis: Tackling tunicamycin
ED Goddard-Borger, SG Withers
Nature Chemistry | NATURE PUBLISHING GROUP | Published : 2012
DOI: 10.1038/nchem.1391
Abstract
The tunicamycins, secondary metabolites of various Streptomyces species, are invaluable tools in glycobiology. It has now been shown that their biosynthesis involves an unusual exo-glycal intermediate produced by previously unknown short-chain dehydrogenase/reductase activity.