Journal article
Runx2 in normal tissues and cancer cells: A developing story
K Blyth, F Vaillant, A Jenkins, L McDonald, MA Pringle, C Huser, T Stein, J Neil, ER Cameron
Blood Cells Molecules and Diseases | Published : 2010
Abstract
The Runx transcription factors are essential for mammalian development, most notably in the haematopoietic and osteogenic lineages. Runx1 and its binding partner, CBFβ, are frequently targeted in acute leukaemia but evidence is accumulating that all three Runx genes may have a role to play in a wider range of cancers, either as tumour promoters or tumour suppressors. Whilst Runx2 is renowned for its role as a master regulator of bone development we discuss here its expression pattern and putative functions beyond this lineage. Furthermore, we review the evidence that RUNX2 promotes neoplastic development in haematopoietic lineages and in advanced mammary and prostate cancer. © 2010 Elsevier ..
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Funding Acknowledgements
This paper is based on a presentation at the EMBO Workshop on RUNX transcription factors in development and disease, held in Oxford, August 16-19, 2009. This EMBO Workshop was co-sponsored by the NIH Office of Rare Diseases, Company of Biologists, MRC Molecular Haematology Unit, Leukaemia Research Fund, Heinrich Pette Institut, and the Association for International Cancer Research. Work carried out is supported by the Association for International Cancer Research, Cancer Research UK and Leukaemia and Lymphoma Research. The authors are grateful for excellent technical support provided by Margaret Bell. The authors declare no conflicts of interest.