An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
C Sheridan, G Brumatti, M Elgendy, M Brunet, SJ Martin
Oncogene | NATURE PUBLISHING GROUP | Published : 2010
Awarded by Science Foundation Ireland
Awarded by Irish Cancer Society
We thank Dr Julian Downward, Dr Richard Marais and Dr Maria Soengas for provision of Ras, B-Raf and Bax/Bak shRNA expression plasmids, respectively; Dr Eric Eldering for provision of shRNA constructs against Noxa and Mcl-1; Dr Dean Fennell for provision of H460 cells and for very useful discussions; Dr Yihong Ye for provision of shRNA constructs against ATF4 and Dr Hans van Dam for provision of shRNA constructs against Fra1 and ATF3. We thank Science Foundation Ireland (08/IN.1/B203) and The Irish Cancer Society (CRP08MAR) for support of this work. GB was supported, in part, by an IRCSET post-doctoral fellowship. CS was supported, in part, by an IRCSET PhD studentship. SJM is a Science Foundation Ireland Principal Investigator.