Journal article

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

O Alpdogan, VM Hubbard, OM Smith, N Patel, S Lu, GL Goldberg, DH Gray, J Feinman, AA Kochman, JM Eng, D Suh, SJ Muriglan, RL Boyd, MRM van den Brink

Blood | AMER SOC HEMATOLOGY | Published : 2006


Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that mediates epithelial cell proliferation and differentiation in a variety of tissues, including the thymus. We studied the role of KGF in T-cell development with KGF-/- mice and demonstrated that thymic cellularity and the distribution of thymocyte subsets among KGF-/-, wildtype (WT), and KGF+/- mice were similar. However, KGF-/- mice are more vulnerable to sublethal irradiation (450 cGy), and a significant decrease was found in thymic cellularity after irradiation. Defective thymopoiesis and peripheral T-cell reconstitution were found in KGF-/- recipients of syngeneic or allogeneic bone marrow transplant,..

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University of Melbourne Researchers