Enhanced efficacy of 90Y-radiolabeled anti-lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model

Abstract

Radioimmunotherapy (RIT) of solid tumor is often limited in efficacy because of restrictions in achieved tumor dose. In an effort to overcome this, the combination of RIT with other therapeutic modalities was investigated in an animal model of breast carcinoma. The rationale for this combined-modality RIT (CMRIT) was to increase the therapeutic efficacy of RIT through the use of paclitaxel to arrest cells in the radiosensitive G2/M phase of the cell cycle. Methods: In this study, the biodistribution and therapeutic efficacy of 90Y-radiolabeled humanized anti-Lewis Y hu3S193 monoclonal antibody (90Y-hu3S193) RIT in combination with paclitaxel chemotherapy was explored in a Lewis Y-expressing ..