Seroepidemiology of dengue in travellers: A paired sera analysis
Karin Leder, Margot Mutsch, Patricia Schlagenhauf, Christine Luxemburger, Joseph Torresi
TRAVEL MEDICINE AND INFECTIOUS DISEASE | ELSEVIER SCI LTD | Published : 2013
BACKGROUND: Dengue is a frequent cause of fever in travellers. The true extent is unknown as many infections are asymptomatic or undiagnosed. METHODS: We used paired sera, with pre- and post-travel specimens from Swiss travellers to tropical destinations, to evaluate the seroepidemiology of travel-related dengue. Post-travel specimens were tested for the presence of IgG and IgM antibodies to dengue antigen serotypes (1, 2, 3 and 4) using an indirect enzyme-linked immunosorbent assay (ELISA). All post-travel sera that screened as positive for dengue IgG or IgM antibodies were re-tested with the corresponding pre-travel sera as paired assays in order to detect seroconversion. RESULTS: There we..View full abstract
J. Torresi received an unrestricted investigator initiated research grant from Sanofi Pasteur to perform this sero-veraprevalence study. C. Luxemburger is an employee of Sanofi Pasteur.