Journal article

A randomised controlled trial of plasma filtration in severe paediatric sepsis

Elliot J Long, Frank Shann, Gale Pearson, David Buckley, Warwick Butt

CRITICAL CARE AND RESUSCITATION | AUSTRALASIAN MED PUBL CO LTD | Published : 2013

Abstract

OBJECTIVE: To determine whether plasma filtration improves 28-day survival in infants and children with severe sepsis. DESIGN: A multicentre randomised controlled trial. SETTING: Paediatric intensive care units in teaching hospitals. PATIENTS: Forty-eight infants and children with severe sepsis. INTERVENTIONS: Patients were randomly assigned to receive plasma filtration (n = 25) or standard therapy (n = 23) for the treatment of septic shock. The primary outcome measure was 28-day survival. Secondary outcome measures included the number of failed organ systems on Day 7, a requirement for extracorporeal membrane oxygenation (ECMO), and the modified Glasgow outcome score (MGOS) at 6 months (whe..

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