A randomised controlled trial of plasma filtration in severe paediatric sepsis

Abstract

Objective: To determine whether plasma filtration improves 28-day survival in infants and children with severe sepsis. Design: A multicentre randomised controlled trial. Setting: Paediatric intensive care units in teaching hospitals. Patients: Forty-eight infants and children with severe sepsis. Interventions: Patients were randomly assigned to receive plasma filtration (n = 25) or standard therapy (n = 23) for the treatment of septic shock. The primary outcome measure was 28-day survival. Secondary outcome measures included the number of failed organ systems on Day 7, a requirement for extracorporeal membrane oxygenation (ECMO), and the modified Glasgow outcome score (MGOS) at 6 months (whe..