Journal article
The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI
KD Harrington, YY Lim, KA Ellis, C Copolov, D Darby, M Weinborn, D Ames, RN Martins, G Savage, C Szoeke, C Rowe, VL Villemagne, CL Masters, P Maruff
International Psychogeriatrics | Published : 2013
Abstract
Background: To date evidence of the relationship between cognition and Aβ amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia. Methods: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for Aβ amyloid. Results: Within the MCI group individuals with high Aβ amyloid sho..
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Funding Acknowledgements
Core funding for the AIBL study was provided by the Commonwealth Scientific and Industrial Research Organisation (CSIRO), which was supplemented by "in kind" contributions from the study partners (see http://www.aibl.csiro.au/). The research was also supported by the Science Industry and Endowment Fund (see www.sief.org.au), and the National Health and Medical Research Council (NHMRC) via the Dementia Collaborative Research Centres program (DCRC2). Mental Health Research Institute (MHRI) acknowledges the funding support from the Victorian Government's Operational Infrastructure Support program. Pfizer International has contributed financial support to assist with the analysis of blood samples and to further the AIBL research program. The McCusker Foundation has contributed financial and in-kind support to AIBL. The authors acknowledge the financial support of the Cooperative Research Centre (CRC) for Mental Health program.