Journal article
Effects of Maternal Obstructive Sleep Apnoea on Fetal Growth: A Prospective Cohort Study
AM Fung, DL Wilson, M Lappas, M Howard, M Barnes, F O'Donoghue, S Tong, H Esdale, G Fleming, SP Walker
Plos One | Published : 2013
Abstract
Objective:The objective of this study is to determine whether obstructive sleep apnea (OSA) is associated with reduced fetal growth, and whether nocturnal oxygen desaturation precipitates acute fetal heart rate changes.Study Design:We performed a prospective observational study, screening 371 women in the second trimester for OSA symptoms. 41 subsequently underwent overnight sleep studies to diagnose OSA. Third trimester fetal growth was assessed using ultrasound. Fetal heart rate monitoring accompanied the sleep study. Cord blood was taken at delivery, to measure key regulators of fetal growth.Results:Of 371 women screened, 108 (29%) were high risk for OSA. 26 high risk and 15 low risk wome..
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Funding Acknowledgements
The authors acknowledge the funding support for this project from the Victorian Managed Insurance Agency, the Australian Stillbirth Alliance, the Medical Research Foundation for Women and Babies and the Austin Medical Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.