Journal article

Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

Yi Zhu, Karla MP Pires, Kevin J Whitehead, Curtis D Olsen, Benjamin Wayment, Yi Cheng Zhang, Heiko Bugger, Olesya Ilkun, Sheldon E Litwin, George Thomas, Sara C Kozma, E Dale Abel

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013

Abstract

Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia have all been implicated as playing roles in disease progression. P. gingivalis cell-surface-located protease/adhesins, the gingipains, have been suggested to be involved in its interactions with several other bacterial species. The aims of this study were to determine polymicrobial biofilm formation by P. gingivalis, T. denticola and T. forsythia, as well as the role of P. gingivalis gingipains in biofilm formation by using a gingipain null triple mutan..

View full abstract