The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.
Lilach Sheiner, Akhil B Vaidya, Geoffrey I McFadden
CURRENT OPINION IN MICROBIOLOGY | CURRENT BIOLOGY LTD | Published : 2013
The apicoplast and the mitochondrion of Apicomplexa cooperate in providing essential metabolites. Their co-evolution during the ancestral acquisition of a plastid and subsequent loss of photosynthesis resulted in divergent metabolic pathways compared with mammals and plants. This is most evident in their chimerical haem synthesis pathway. Toxoplasma and Plasmodium mitochondria operate canonical tricarboxylic acid (TCA) cycles and electron transport chains, although the roles differ between Toxoplasma tachyzoites and Plasmodium erythrocytic stages. Glutamine catabolism provides TCA intermediates in both parasites. Isoprenoid precursor synthesis is the only essential role of the apicoplast in ..View full abstract
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We thank Boris Striepen and Muthugapatti Kandasamy for access and assistance in utilizing a Zeiss ELYRA S1 (SR-SIM) for super resolution microscopy. LS is supported by an NIH pathway to independence award (K99-AI103032). ABV is supported by NIH grants (R01-A1028398, R01-AI098413 and R56-AI100569). GMcF is supported by the Australian Research Council and a Program Grant from the National Health and Medical Research Council.