Journal article

Rapid Deletion and Inactivation of CTLs upon Recognition of a Number of Target Cells over a Critical Threshold

Sandro Prato, Yifan Zhan, Justine D Mintern, Jose A Villadangos

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2013

Abstract

Initiation of CTL responses against foreign pathogens also primes anti-self CTLs. Mechanisms of CTL inactivation inhibit anti-self CTLs to prevent tissue damage. These mechanisms are exploited by pathogens and tumors to evade the immune response, and present a major hurdle to adoptive CTL therapies. It is unclear whether CTL inactivation is Ag specific and, if so, which APCs are involved. Potential candidates include the target cells themselves, dendritic cells, myeloid-derived suppressor cells, and macrophages. In this study, we show that lymphoma-specific CTLs are rapidly deleted in an Ag-specific manner after adoptive transfer into lymphoma-bearing mice, and the surviving CTLs are functio..

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Grants

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia, the University of Melbourne, and the Leukemia and Lymphoma Society. J.A.V. is a National Health and Medical Research Council of Australia Senior Research Fellow, and J.D.M. is a National Health and Medical Research Council of Australia Career Development Fellow.