Journal article
Seasonality of Kawasaki Disease: A Global Perspective
JC Burns, L Herzog, O Fabri, AH Tremoulet, X Rodó, R Uehara, D Burgner, E Bainto, D Pierce, M Tyree, D Cayan
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Background:Understanding global seasonal patterns of Kawasaki disease (KD) may provide insight into the etiology of this vasculitis that is now the most common cause of acquired heart disease in children in developed countries worldwide.Methods:Data from 1970-2012 from 25 countries distributed over the globe were analyzed for seasonality. The number of KD cases from each location was normalized to minimize the influence of greater numbers from certain locations. The presence of seasonal variation of KD at the individual locations was evaluated using three different tests: time series modeling, spectral analysis, and a Monte Carlo technique.Results:A defined seasonal structure emerged demonst..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
This work was supported in part by grants from the National Institutes of Health, National Heart, Lung, Blood Institute (HL69413 and iDASH U54-HL108460) awarded to JCB, by La Marato de TV3 Foundation ('Malaties cardiovasculars 2007') to XR, and by the National Oceanographic and Atmospheric Administration Regional Integrated Sciences and Assessments through the California Nevada Applications Program, through the National Oceanographic and Atmospheric Administration Regional Integrated Science Assessments program, awarded to DC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.