Journal article
Riquiqui and minibrain are regulators of the Hippo pathway downstream of Dachsous
JL Degoutin, CC Milton, E Yu, M Tipping, F Bosveld, L Yang, Y Bellaiche, A Veraksa, KF Harvey
Nature Cell Biology | Published : 2013
DOI: 10.1038/ncb2829
Abstract
The atypical cadherins Fat (Ft) and Dachsous (Ds) control tissue growth through the Salvador-Warts-Hippo (SWH) pathway, and also regulate planar cell polarity and morphogenesis. Ft and Ds engage in reciprocal signalling as both proteins can serve as receptor and ligand for each other. The intracellular domains (ICDs) of Ft and Ds regulate the activity of the key SWH pathway transcriptional co-activator protein Yorkie (Yki). Signalling from the FtICD is well characterized and controls tissue growth by regulating the abundance of the Yki-repressive kinase Warts (Wts). Here we identify two regulators of the Drosophila melanogaster SWH pathway that function downstream of the DsICD: the WD40 repe..
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Awarded by University of Melbourne
Funding Acknowledgements
We thank C. House for assistance with mass spectrometry, J. Lin and K. Hannan for expertise with kinase assays and S. Blair (University of Madison, Wisconsin, USA), I. Edery (Rutgers University, USA), C. House (Peter MacCallum Cancer Centre, Australia), K. Irvine (Rutgers University, USA), D. Pan (Johns Hopkins University, USA), M. Simon (Stanford University, USA), D. Strutt, University of Sheffield, UK), N. Tapon (Cancer Research UK, UK), F. Tejedor (Universidad Miguel Hernandez, Spain), K. Yu (Korea Research Institute of Bioscience and Biotechnology), the Developmental Studies Hybridoma Bank, the Vienna Drosophila RNAi Center, the Australian Drosophila Research Support Facility (www.ozdros.com), the National Institute of Genetics and the Bloomington Stock Centre for fly stocks, plasmids and antibodies. K.F.H. is a Sylvia and Charles Viertel Senior Medical Research Fellow. This research was supported by a Project Grant from the National Health and Medical Research Council of Australia, and by NIH grants GM097727 and CA156734 and NSF grant 0640700 to A.V. Mass spectrometry was performed at the Taplin Facility, Harvard Medical School, USA and Bio21, University of Melbourne, Australia.