Journal article

NKT cells: the smoking gun in fungal-induced asthma?

Dale I Godfrey, Daniel G Pellicci, Jamie Rossjohn

NATURE MEDICINE | NATURE PUBLISHING GROUP | Published : 2013

DOI: 10.1038/nm.3360

Abstract

Aspergillus fumigatus is a fungus that is associated with a severe form of asthma, although the precise immunological basis for this disease is unclear. A new study in mice shows that natural killer T (NKT) cells are crucial for progression of A. fumigatus–induced asthma and also identifies a glycolipid antigen from this fungus that seems to drive this NKT cell–mediated inflammatory response (pages 1297–1304).

University of Melbourne Researchers

Dale Godfrey Author Microbiology and Immunology

Daniel Pellicci Author Microbiology and Immunology

Related Projects (4)

RESEARCH FELLOWSHIP

Professor Godfrey is an immunologist with a long standing history as a pioneer in the study of a specialised type of white blood cell, known..

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2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY)

The immune system plays an important role in protecting the host from viral and bacterial infections, and inhibits cancer onset and progress..

2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY)

The immune system plays an important role in protecting the host from viral and bacterial infections, and inhibits cancer onset and progress..

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Keywords

Life Sciences & Biomedicine

Aspergillus Fumigatus

Medicine, Research & Experimental

Glycosphingolipids

Bronchial Hyperreactivity

2.1 Biological and Endogenous Factors

Biochemistry & Molecular Biology

Science & Technology

Natural Killer T-Cells

Infectious Diseases

Research & Experimental Medicine