Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte
Laura A Bienvenu, Melissa E Reichelt, Lea MD Delbridge, Morag J Young
CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2013
MR (mineralocorticoid receptor) activation in the heart plays a central role in the development of cardiovascular disease, including heart failure. The MR is present in many cell types within the myocardium, including cardiomyocytes, macrophages and the coronary vasculature. The specific role of the MR in each of these cell types in the initiation and progression of cardiac pathophysiology is not fully understood. Cardiomyocyte MRs are increasingly recognized to play a role in regulating cardiac function, electrical conduction and fibrosis, through direct signal mediation and through paracrine MR-dependent activity. Although MR blockade in the heart is an attractive therapeutic option for th..View full abstract
This work was supported by the National Health and Medical Research Council (Australia) and by the Victorian Government's Operational Infrastructure Support Program. L.A.B was supported by an Australian Postgraduate Award.