Journal article

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A

Dalia Kasperaviciute, Claudia B Catarino, Mar Matarin, Costin Leu, Jan Novy, Anna Tostevin, Barbara Leal, Ellen VS Hessel, Kerstin Hallmann, Michael S Hildebrand, Hans-Henrik M Dahl, Mina Ryten, Daniah Trabzuni, Adaikalavan Ramasamy, Saud Alhusaini, Colin P Doherty, Thomas Dorn, Joerg Hansen, Guenter Kraemer, Bernhard J Steinhoff Show all

Brain | OXFORD UNIV PRESS | Published : 2013

Grants

Awarded by Wellcome Trust


Awarded by UK Medical Research Council (MRC)


Awarded by University College London Hospitals Charities and the Clinical Research and Development Committee (UCLH/CRDC)


Awarded by National Institute for Health Research (NIHR)


Awarded by European Commission


Awarded by University of Tubingen (IZEPHA project)


Awarded by German Federal Ministry of Education and Research, National Genome Research Network (NGFNplus: EMINet)


Awarded by German Research Foundation


Awarded by Austrian Science Fund


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Foundation of Science and Technology, Lisbon (FCT)


Awarded by National Institutes of Health, USA (NIH)


Awarded by Irish Higher Education Authority Programme for Research in Third Level Institutions (PRTLI3) through a Science Foundation Ireland Research Frontiers Programme award


Awarded by Medical Research Charities Group of Ireland/Health Research Board award from Brainwave-the Irish Epilepsy Association


Awarded by Fonds National de la Recherche Scientifique


Awarded by UK Medical Research Council


Awarded by Medical Research Council


Awarded by Epilepsy Research UK


Funding Acknowledgements

Supported by the Wellcome Trust (grant 084730 to S. M. S., N.D, C. D.); the UK Medical Research Council (MRC grants G0400126 to S. M. S., G1100616 to C. S., G0901254 to J.H. and M. E. W., and Training Fellowship G0802462 to M. R.); the King Faisal Specialist Hospital and Research Centre (KFSH & RC grant to D. T.); the University College London Hospitals Charities and the Clinical Research and Development Committee (UCLH/CRDC grant F136 to S. M. S.); the National Institute for Health Research (NIHR grant 08-08-SCC to S. M. S.); the National Society for Epilepsy; the National Institute for Health Research University College London Hospitals Biomedical Research Centre; Marie Curie International Re-integration Grant (FP7-PEOPLE-2009-RG grant No 256545 to M. M. and S. M. S.); the European Commission (FP7 project EpiPGX, grant 279062 to H. L., S. M. S and W. S. K.; FP6 project Epicure, grant LSHM-CT-2006-037315 to H. L., P. S. R. and F. R.); the Robert Bosch Foundation, Stuttgart, and the University of Tubingen (IZEPHA project 18-0-0, grant to H. L.); the German Federal Ministry of Education and Research, National Genome Research Network (NGFNplus: EMINet grant 01GS08123 to H. L., S. S., A.J.B.); BONFOR (S. S., A.J.B.); the German Federal Ministry of Education and Research (independent research groups in neuroscience); the German Research Foundation (EUROCORES program, EuroEPINOMICS-RES grant RO3396/2-1 to P. S. R. and F. R. and EuroEPINOMICS-RES grant DFG Bl421/3-1 to I. B. and K. K.); the Austrian Science Fund (project FWF I643, grant to F. Zimprich); the National Health and Medical Research Council (NHMRC grant 628952 to S. F. B.); the Royal Melbourne Hospital Neuroscience Foundation (grant to T.J.O'B.); the Foundation of Science and Technology, Lisbon (FCT grant PIC/IC/83297/2007 to B. M. S.); the National Institutes of Health, USA (NIH grants R01-NS-49306-01 to R.J.B. and R01-NS-064154-01 to R.J.B. and H. H.); the collection of the Irish patient cohort was supported by the Irish Higher Education Authority Programme for Research in Third Level Institutions (PRTLI3) through a Science Foundation Ireland Research Frontiers Programme award (08/RFP/GEN1538) and a Medical Research Charities Group of Ireland/Health Research Board award (2009/001) from Brainwave-the Irish Epilepsy Association. GlaxoSmithKline funded the recruitment and phenotypic data collection of the GenEpA Consortium samples used in this study and contributed to the genotyping costs associated with their study. The collection of the Belgian patients was supported by the Fonds National de la Recherche Scientifique, grant n. FC 63574/3.4.620.06 F, and the Fonds Erasme, Universite Libre de Bruxelles. The collection of the Belgian control cohort was supported by the Walloon Region and the French-Speaking Community of Belgium, the Belgian Science Policy and the University of Liege. J.N. is supported by the Swiss National Science Foundation-Fellowships for prospective researchers and the SICPA Foundation, Prilly, Switzerland. Computing facilities used at King's College London were supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. Funding support for the ALSPAC was provided by The UK Medical Research Council (grant refs: 74882) the Wellcome Trust (grant refs: 076467) and the University of Bristol.This study makes use of data generated by the Wellcome Trust Case-Control Consortium (a full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk; funding for the project was provided by the Wellcome Trust under award 076113 and 085475) and the Irish Amyotrophic Lateral Sclerosis Study (funding support was provided by Muscular Dystrophy Association, USA, Irish Institute of Clinical Neurosciences Travel Award, and National Institutes of Health, USA; additional genotyping was provided by the National Institute of Neurological Disorders and Stroke (NINDS); the dataset used for the analyses described in this manuscript were obtained from the NINDS Database found at http://www.ncbi.nlm.nih.gov/gap through dbGaP accession number phs000127.v1.p1).