Journal article

An FtsH Protease Is Recruited to the Mitochondrion of Plasmodium falciparum

Aiman Tanveer, Stacey M Allen, Katherine E Jackson, Manish Charan, Stuart A Ralph, Saman Habib

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013

Abstract

The two organelles, apicoplast and mitochondrion, of the malaria parasite Plasmodium falciparum have unique morphology in liver and blood stages; they undergo complex branching and looping prior to division and segregation into daughter merozoites. Little is known about the molecular processes and proteins involved in organelle biogenesis in the parasite. We report the identification of an AAA+/FtsH protease homolog (PfFtsH1) that exhibits ATP- and Zn(2+)-dependent protease activity. PfFtsH1 undergoes processing, forms oligomeric assemblies, and is associated with the membrane fraction of the parasite cell. Generation of a transfectant parasite line with hemagglutinin-tagged PfFtsH1, and imm..

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University of Melbourne Researchers

Grants

Awarded by CSIR Network Project


Awarded by Australian Research Council


Funding Acknowledgements

AT received a research fellowship from the Council of Scientific and Industrial Research, Government of India (CSIR; http://www.csir.res.in/home.asp). This work was supported by CSIR Network Project (NWP-0038 and SPLendid) grants to SH. SAR is supported by an Australian Research Council Future Fellowship (FT0990350). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.