Journal article
Renal structure in normoalbuminuric and albuminuric patients with type 2 diabetes and impaired renal function
EI Ekinci, G Jerums, A Skene, P Crammer, D Power, KY Cheong, S Panagiotopoulos, K McNeil, ST Baker, P Fioretto, RJ MacIsaac
Diabetes Care | AMER DIABETES ASSOC | Published : 2013
DOI: 10.2337/dc12-2572
Abstract
OBJECTIVE-The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measured GFR of <60 mL/min/1.73 m2, associated with either normo-, micro-, or macroalbuminuria. RESEARCH DESIGN AND METHODS-In patients with normo- (n = 8) ormicroalbuminuria (n = 6), renal biopsies were performed according to a research protocol. In patients with macroalbuminuria (n = 17), biopsies were performed according to clinical indication. Findings were categorized according to the Fioretto classification: category 1 (C1), normal/near norm..
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Awarded by Seventh Framework Programme
Funding Acknowledgements
E.I.E. was supported by a National Health and Medical Research Council (NHMRC) post-graduate scholarship and an NHMRC Early Career Fellowship (1054312). This project was supported by an NHMRC project grant (266505).