Journal article
Brain Structural Alterations in Obsessive-Compulsive Disorder Patients with Autogenous and Reactive Obsessions
M Subirà, P Alonso, C Segalàs, E Real, C López-Solà, J Pujol, I Martínez-Zalacaín, BJ Harrison, JM Menchón, N Cardoner, C Soriano-Mas
Plos One | Published : 2013
Abstract
Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consistently reported in OCD, their interaction with particular clinical subtypes deserves further examination. Among other approaches, a two-group classification in patients with autogenous and reactive obsessions has been proposed. The purpose of the present study was to assess, by means of a voxel-based morphometry analysis, the putative brain structural correlates of this classification scheme in OCD patients. Ninety-five OCD patients and 95 healthy controls were recruited. Patients were divided into autogenous (n = 30) and reactive (n = 65) sub-groups. A structura..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported in part by the Carlos III Health Institute (PI09/01331 PI10/01753, PI10/01003, CP10/00604, CIBER-CB06/03/0034) and by the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR; 2009SGR1554). M. S. is funded by the Bellvitge Biomedical Research Institute (IDIBELL). E. R. is supported by a 'Rio Hortega' contract from the Carlos III Health Institute (I. D. CM11/00077). C. L-S. is supported by the Spanish Ministry of Education, Culture and Sport (FPU12/01636). B. H. is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I. D. 628509). C.S-M. is funded by a 'Miguel Servet' contract from the Carlos III Health Institute (CP10/00604). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.