Journal article
Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice
B Abegaz, PJ Davern, KL Jackson, TP Nguyen-Huu, JK Bassi, A Connelly, YT Choong, AM Allen, GA Head
Cardiovascular Research | OXFORD UNIV PRESS | Published : 2013
DOI: 10.1093/cvr/cvt183
Abstract
Aims: The nucleus of the solitary tract (NTS) is important for cardiovascular regulation and contains angiotensin type 1A (AT1A) receptors. To assess its function, we examined the effect of expressing in AT1A receptors in the NTS of mice lacking these receptors. Methods and results: Bilateral microinjections of lentivirus expressing AT1A receptors (AT1Av mice, n = 6) or green fluorescent protein (GFPv, n = 8, control) under the control of the PRSx8 promotor were made into the NTS of AT1A receptors null mice (AT1A-/-). Telemetry devices recorded blood pressure (BP), heart rate (HR), and locomotor activity. Expression of AT1A receptors in the NTS increased BP by 11.2 ± 4 mmHg (P < 0.05) at 2 a..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (project grant 526662), NHMRC Fellowship award (367631 to G. A. H.), and NHMRC/National Heart Foundation Post Doctoral Fellowship (APP1012881 to P.J.D.). The study was supported in part by Victorian Government's operational Infrastructure Support Program.