Journal article
TCF-1 controls ILC2 and NKp46 RORγt innate lymphocyte differentiation and protection in intestinal inflammation
LA Mielke, JR Groom, LC Rankin, C Seillet, F Masson, T Putoczki, GT Belz
Journal of Immunology | Published : 2013
Abstract
Innate lymphocyte populations play a central role in conferring protective immunity at the mucosal frontier. In this study, we demonstrate that T cell factor 1 (TCF-1; encoded byTcf7), a transcription factor also important for NK and T cell differentiation, is expressed by multiple innate lymphoid cell (ILC) subsets, including GATA3+ nuocytes (ILC2) and NKp46+ ILCs (ILC3), which confer protection against lung and intestinal inflammation. TCF-1 was intrinsically required for the differentiation of both ILC2 and NKp46 + ILC3. Loss of TCF-1 expression impaired the capacity of these ILC subsets to produce IL-5, IL-13, and IL-22 and resulted in crippled responses to intestinal infection withCitro..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Awarded by Cancer Australia
Funding Acknowledgements
This work was supported by a project grant (APP1047903) from the National Health and Medical Research Council of Australia, the Victorian State Government Operational Infrastructure Support, and an Australian Government National Health and Medical Research Council (NHMRC) Independent Research Institutes Infrastructure Support scheme. L. A. M. was supported by a Cancer Australia grant (APP1050241), J.R.G. was supported by an NHMRC postgraduate training fellowship, L. C. R. was supported by an NHMRC Dora Lush Biomedical postgraduate scholarship, and G. T. B. was supported by an Australian Research Council Future Fellowship.