Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample
Michelle L Byrne, Neil M O'Brien-Simpson, Eric C Reynolds, Katrina A Walsh, Katrina Laughton, Joanna M Waloszek, Michael J Woods, John Trinder, Nicholas B Allen
BRAIN BEHAVIOR AND IMMUNITY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2013
Recent research has examined associations between inflammation and mental health, and has increasingly focused on utilising younger samples to characterise the temporal relationship between inflammatory responses and the emergence of other symptoms. These studies have typically used blood to measure inflammation, although rates of detection for many inflammatory markers appear to be low. Saliva is a safe and low-cost alternative, and adult research has shown that levels of some salivary markers correlate well with those in serum. However, no research has examined this association in young people. This study examined 16 inflammatory markers in serum and saliva in 17 depressed adolescents and ..View full abstract
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Awarded by Australian Government National Health and Medical Research Council grant (NHMRC)
This work was supported by an Australian Government National Health and Medical Research Council grant (NHMRC; APP1029878) and an internal grant from the Melbourne School of Psychological Sciences, The University of Melbourne, Australia. Blood collection services were provided by the Melbourne Health Shared Pathology Service, Melbourne, Australia.