Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases
Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O'Leary, Michelle E Ehrlich, Guenter Schuetz, Andrew J Lawrence, John Drago
BMC NEUROSCIENCE | BMC | Published : 2013
BACKGROUND: Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which Huntington disease (HD) is the prototypical example. In HD, death occurs in striatal projection neurons as well as cortical neurons. Cortical and striatal neurons that express the D1 dopamine receptor (Drd1a) degenerate in HD. The contribution that death of specific neuronal cell populations makes to the HD disease phenotype and the response of the brain to loss of defined cell subtypes is largely unknown. METHODS: Drd1a-expressing cells were targeted for cell death and three independent lines generated; a striatal-restricted line, a cortical-restricted line and a ..View full abstract
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Awarded by National Health AMP; Medical Research Council (NHMRC) of Australia
This work was supported by project grants from the National Health & Medical Research Council (NHMRC) of Australia  and  and the Victorian Government's Operational Infrastructure Support Program. JD and AJL are Fellows of the NHMRC.