Journal article
Defining phenotypic causes of obstructive sleep apnea: Identification of novel therapeutic targets
DJ Eckert, DP White, AS Jordan, A Malhotra, A Wellman
American Journal of Respiratory and Critical Care Medicine | Published : 2013
Abstract
Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary amongpatients but havenot been well characterized. Objectives: To define carefully the proportion of key anatomic and nonanatomic contributions in a relatively large cohort of patients with OSA and control subjects to identify pathophysiologic targets for future novel therapies for OSA. Methods: Seventy-five men and women with and without OSA aged 20-65 years were studied on three separate nights. Initially, the apnea-hypopnea index was determined by polysomnography followed by determination of anatomic (passive critical closing pressure of the upper airway [Pcrit]) and nonanatomic (genioglossus muscle respon..
View full abstractGrants
Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
Supported by NIH 5R01HL048531. The authors have also received funding support from the AHA (0840159N, 10SDG3510018); the ARC (60702); the NHMRC of Australia (510392, 1049814); and the NIH (RO1 102231, R01 HL090897, NIH K24 HL 093218, NIH P01 HL 095491, NIH R01HL110350, and NIH R01 HL085188). The Harvard Catalyst is funded by UL1 RR 025758-01. A modified continuous positive airway pressure machine was provided by Philips Respironics and was used to obtain the physiologic measurements performed in this study.