Journal article
Skeletal muscle abnormalities and exercise capacity in adults with a Fontan circulation
Rachael Cordina, Shamus O'Meagher, Haslinda Gould, Caroline Rae, Graham Kemp, Julie A Pasco, David S Celermajer
HEART | BMJ PUBLISHING GROUP | Published : 2013
Abstract
OBJECTIVES: The peripheral muscle pump is key in promoting cardiac filling during exercise, especially in subjects who lack a subpulmonary ventricle (the Fontan circulation). A muscle-wasting syndrome exists in acquired heart failure but has not been assessed in Fontan subjects. We sought to investigate whether adults with the Fontan circulation exhibit reduced skeletal muscle mass and/or metabolic abnormalities. DESIGN AND PATIENTS: Sixteen New York Heart Association Class I/II Fontan adults (30±2 years) underwent cardiopulmonary exercise testing and lean mass quantification with dual x-ray absorptiometry (DXA); eight had calf muscle (31)P magnetic resonance spectroscopy as did eight health..
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