Journal article

The G-Protein-Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis

Leonid L Nikitenko, Russell Leek, Stephen Henderson, Nischalan Pillay, Helen Turley, Daniele Generali, Sarah Gunningham, Helen R Morrin, Andrea Pellagatti, Margaret CP Rees, Adrian L Harris, Stephen B Fox



PURPOSE: The G-protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers. We therefore investigated the diagnostic/prognostic use for CLR in human tumor types that may rely on adrenomedullin signaling and in clear cell renal cell carcinoma (RCC), a highly vascular tumor, in particular. EXPERIMENTAL DESIGN: In silico gene expression mRNA profiling microarray study (n = 168 tumors) and cancer profiling cDNA array hybridization (n = 241 pairs of patient-matched tumor/normal tissue samples) were carried out to analyze ADM mRNA expressi..

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Awarded by Cancer Research UK

Awarded by Wellcome Trust

Funding Acknowledgements

This study was supported in part by the Cancer Research UK (grants C575/A6125 and C575/A13100; to L. L. Nikitenko, D. Generali, S. Henderson, A. L. Harris, and S. B. Fox), The Wellcome Trust (grant 063353/Z/00Z; to L. L. Nikitenko and M. C. P. Rees), The Cancer Society, Canterbury West Coast Division, NZ(to H. R. Morrin), Medical Research Fund, University of Oxford, United Kingdom (to L. L. Nikitenko), The Royal Society UK, Cancer Research UK and The Maurice & Phyllis Paykel Trust travel awards (to L. L. Nikitenko).