Journal article

Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase

Haiying Bie, Jiang Yin, Xu He, Allison R Kermode, Ethan D Goddard-Borger, Stephen G Withers, Michael NG James

Nature Chemical Biology | NATURE PUBLISHING GROUP | Published : 2013


Awarded by Canadian Institutes for Health Research

Awarded by Michael Smith Foundation for Health Research

Funding Acknowledgements

This paper is dedicated to the memory of John Colter (1923-2013), chair of the Department of Biochemistry, University of Alberta, from 1961 to 1987. We thank S. Khan for his technical assistance during in-house data collection and the staff at the Canadian Light Source in Saskatoon and the Stanford Synchrotron Radiation Lightsource for their assistance in the data collection. We are grateful for the initial work done by K. Bateman on the growth of the monoclinic form of IDUA crystals, for synthetic work performed by A. Wong and for the expression and purification of CBM-PNGase-F by E. Kwan. We also thank J. Hopwood for the monoclonal antibody to human IDUA. M.N.G. J. and A.R.K. are grateful for the funding support from the Canadian Institutes for Health Research (grant no. MOP123222). H.B. thanks Alberta Innovates Health Solution for the fellowship support. E.D.G.-B. thanks the Canadian Institute of Health Research for a postdoctoral fellowship. A.R.K. is grateful for funding support from the Canadian Society for Mucopolysaccharide and Related Diseases and to the Michael Smith Foundation for Health Research for the Senior Scholar Award (award no. CI-SSH-01915(07-1)).