Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

S Jegaskanda; KL Laurie; TH Amarasena; WR Winnall; M Kramski; R De Rose; IG Barr; AG Brooks; PC Reading; SJ Kent

Journal article

Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

S Jegaskanda, KL Laurie, TH Amarasena, WR Winnall, M Kramski, R De Rose, IG Barr, AG Brooks, PC Reading, SJ Kent

Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2013

DOI: 10.1093/infdis/jit294

Abstract

Background. During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed.Methods. We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC antibodies to the A(H1N1)pdm09 hemagglutinin (HA) protein.Results. A(H1N1)pdm09 HA-specific ADCC antibodies were detected in almost all individuals aged >45 years (28/31 subjects) before the 2009 A(H1N1) ..

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University of Melbourne Researchers

Rob De Rose Author

Ian Barr Author

Andrew Brooks Author

Patrick Reading Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (awards 628331 and 510488). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Aging.