Journal article
Contribution of Brain Size to IQ and Educational Underperformance in Extremely Preterm Adolescents
JLY Cheong, PJ Anderson, G Roberts, AC Burnett, KJ Lee, DK Thompson, C Molloy, M Wilson-Ching, A Connelly, ML Seal, SJ Wood, LW Doyle
Plos One | Published : 2013
Abstract
Objectives:Extremely preterm (EP) survivors have smaller brains, lower IQ, and worse educational achievement than their term-born peers. The contribution of smaller brain size to the IQ and educational disadvantages of EP is unknown. This study aimed (i) to compare brain volumes from multiple brain tissues and structures between EP-born (<28weeks) and term-born (≥37weeks) control adolescents, (ii) to explore the relationships of brain tissue volumes with IQ and basic educational skills and whether this differed by group, and (iii) to explore how much total brain tissue volume explains the underperformance of EP adolescents compared with controls.Methods:Longitudinal cohort study of 148 EP an..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (Project Grant ID 491246 to LD, PA, SW, JC, as well as C. Robertson, S. Hope, and D. Hacking; Centre of Clinical Research Excellence Grant ID 546519; Senior Research Fellowship ID 628371 to PA; Early Career Fellowship ID 1053787 to JC; Early Career Fellowship ID 1012236 to DT; Career Development Fellowship ID 1053609 to KJL) and the Victorian Government Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.