Dengue fever and international travel

Abstract

Background Dengue is a leading public health problem with an expanding global burden. Dengue virus is also a significant cause of illness in international travelers with an increasing number of cases of dengue fever identified in travelers returning from dengue-endemic countries. Methods This review focuses on the clinical illness of dengue infection in international travelers and provides a summary of the risk of infection for travelers, clinical features of infection, and an overview of dengue vaccines and their potential applicability to travelers. Results Four prospective studies of travelers to dengue-endemic destinations have shown that the dengue infection incidence ranges from 10.2 t..