The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells
Kevin Man, Maria Miasari, Wei Shi, Annie Xin, Darren C Henstridge, Simon Preston, Marc Pellegrini, Gabrielle T Belz, Gordon K Smyth, Mark A Febbraio, Stephen L Nutt, Axel Kallies
Nature Immunology | NATURE PUBLISHING GROUP | Published : 2013
We thank T. W. Mak (Campbell Family Cancer Research Institute) for Irf4<SUP>-/-</SUP> mice; U. Klein (Columbia University) for mice with loxP-flanked Irf4 alleles; S. M. Kaech (Yale University School of Medicine) for mice expressing Cre under the control of Gzmb; P. Bouillet (The Walter and Eliza Hall Institute) for Bim<SUP>-/-</SUP> mice; S. Cory (The Walter and Eliza Hall Institute) for mice with transgenic overexpression of Bcl-2 in all hematopoietic cells (Vav-Bcl2tg mice); D. Zehn (Swiss Vaccine Research Institute) for OVA-expressing L. monocytogenes variants; A. M. Lew (The Walter and Eliza Hall Institute) for HKx31-OVA; S. Sterle, R. Cole, N. Iannarella and L. Mackiewicz for technical support; and D. Segal, P. D. Hodgkin, L. M. Corcoran, S. Heinzel, F. Masson (all The Walter and Eliza Hall Institute) and C. Palmer (Burnet Institute) for antibodies and discussions. Supported by the National Health and Medical Research Council of Australia (M. P., G. T. B., G. K. S., S. L. N., M. A. F. and A. K.), the Sylvia and Charles Viertel Foundation (A. K. and G. T. B.), the Howard Hughes Medical Institute (G. T. B.), the Australian Research Council (S. L. N. and A. K.), the National Heart Foundation (D. C. H.) and The Walter and Eliza Hall Institute Genomics Fund (A. K., G. T. B. and W. S.), the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support scheme.