Plasma MIC-1 and PAPP-A Levels Are Decreased among Women Presenting to an Early Pregnancy Assessment Unit, Have Fetal Viability Confirmed but Later Miscarry
Tu'uhevaha J Kaitu'u-Lino, Katerina Bambang, Joseph Onwude, Richard Hiscock, Justin Konje, Stephen Tong
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: We have recently shown first trimester Macrophage inhibitory cytokine-1 (MIC-1) and Pregnancy Associated Plasma Protein-A (PAPP-A) serum concentrations are depressed among asymptomatic women destined to miscarry. Here we examined whether plasma levels of MIC-1 and PAPP-A are depressed among women presenting to an Early Pregnancy Assessment Unit (EPAU), noted to have a confirmed viable fetus, but subsequently miscarry. METHODS: We performed a prospective cohort study, recruiting 462 women in the first trimester presenting to EPAU and had fetal viability confirmed by ultrasound. We obtained plasma samples on the same day and measured MIC-1, PAPP-A and human chorionic gonadotrophin ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by the Medical Research Council of UK and National Health and Medical Research Council of Australia (#1050765 #490995). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.