Journal article
SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: A multicenter cohort study and meta-analysis
BS Haerian, L Baum, P Kwan, HJ Tan, AA Raymond, Z Mohamed
Pharmacogenomics | FUTURE MEDICINE LTD | Published : 2013
DOI: 10.2217/pgs.13.104
Abstract
Aim: Approximately a third of newly diagnosed epilepsy patients do not respond to antiepileptic drugs (AEDs). Evidence suggests that low penetrance variants in the genes of drug targets such as voltage-gated sodium channels may be involved in drug responsiveness. To examine this hypothesis, we compared data from two epilepsy cohorts from Malaysia and Hong Kong, as well as a meta-analysis from published data. Materials & methods: Genotype analysis of 39 polymorphisms located in the SCN1A, SCN2A and SCN3A genes was performed on 1504 epilepsy patients from Malaysia and Hong Kong who were receiving AEDs. Meta-analysis was performed for pooled data of SCN1A rs3812718 and rs2298771, and SCN2A rs17..
View full abstractGrants
Awarded by Malaysian Grant HIR MOHE
Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China
Funding Acknowledgements
This study was supported by Malaysian Grant HIR MOHE E000025-20001 and Research Grants Council of the Hong Kong Special Administrative Region, China, Project no. HKU7623/08M, HKU7747/07M and CUHK4466/06M. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.