Journal article

History of trauma and the association with baseline symptoms in an Ultra-High Risk for psychosis cohort

Eva Velthorst, Barnaby Nelson, Karen O'Connor, Nilufar Mossaheb, Lieuwe de Haan, Annie Bruxner, Magenta B Simmons, Alison R Yung, Andrew Thompson



Few studies have addressed the correlates of trauma in young people at Ultra-High Risk (UHR) of developing a psychotic disorder. We aimed to examine baseline differences in intensity, form and content of attenuated positive psychotic symptoms, other clinical symptomatology and comorbidity between UHR patients with and without a history of trauma. In a sample of 127 UHR individuals (53 male, 74 female; mean age 18.2 years, range 14-26) we assessed trauma history and baseline symptomatology using an audit tool developed to retrieve data from patient medical records. 56% of the subjects had experienced at least one type of trauma. The intensity of perceptual abnormalities was significantly high..

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Awarded by NHMRC

Awarded by European Community

Funding Acknowledgements

AT has received a Pfizer Neurosciences Research Grant. BN is supported by an NHMRC Career Development Fellowship (# 1027532). LdH and EV are supported by the European Community's Seventh Framework Program (HEALTH-F2-2009-241909, Project EU-GEI). ARY is the recipient of NHMRC Senior Principal and Senior Research Fellowships respectively. No funding source played any role in the collection, analysis, interpretation or publication of data.AT has been an investigator on trials which received unrestricted investigator-initiated funding from Janssen-Cilag and Astra-Zeneca. ARY has received honoraria and travel support from AstraZeneca, Eli-Lilly, Bristol Meyer Squibb and Janssen-Cilag. LdH has received investigator initiated research grants from Eli Lilly Company and honoraria for lectures from Eli Lilly Company, Janssen-Cilag, and Astra Zeneca.