Journal article
Diffusion-weighted MRI, 11C-choline PET and 18F- fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma
JH Chang, D Lim Joon, ST Lee, CY Hiew, S Esler, SJ Gong, M Wada, D Clouston, R O'Sullivan, YP Goh, H Tochon-Danguy, JG Chan, D Bolton, AM Scott, V Khoo, ID Davis
European Radiology | Published : 2014
Abstract
Objectives: To evaluate the accuracy of transrectal ultrasound-guided (TRUS) biopsy, diffusion-weighted (DW) magnetic resonance imaging (MRI), 11C-choline (CHOL) positron emission tomography (PET), and 18F-fluorodeoxyglucose (FDG) PET in predicting the prostatectomy Gleason risk (GR). Methods: The study included 21 patients who underwent TRUS biopsy and multi-technique imaging before radical prostatectomy. Values from five different tests (TRUS biopsy, DW MRI, CHOL PET, FDG PET, and combined DW MRI/CHOL PET) were correlated with the prostatectomy GR using Spearman's ρ. Tests that were found to have significant correlations were used to classify patients into GR groups. Results: The following..
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Awarded by Department of Health and Ageing, Australian Government
Funding Acknowledgements
This study was supported by grant 487916 through Cancer Australia, Prostate Cancer Foundation Australia, Australian Government Department of Health and Aging. IDD was an Australian National Health and Medical Research Council Practitioner Fellow (487907). The authors gratefully acknowledge the contributions of Graham Hepworth from the Statistical Consulting Centre, University of Melbourne and the staff of the Radiation Oncology Centre, PET Centre and Department of Radiology, Austin Health.