Journal article
Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes
EJ Kezirian, GS Goding, A Malhotra, FJ O'Donoghue, G Zammit, JR Wheatley, PG Catcheside, PL Smith, AR Schwartz, JH Walsh, KJ Maddison, DM Claman, T Huntley, SY Park, MC Campbell, CE Palme, C Iber, PR Eastwood, DR Hillman, M Barnes
Journal of Sleep Research | Published : 2014
DOI: 10.1111/jsr.12079
Abstract
Reduced upper airway muscle activity during sleep is a key contributor to obstructive sleep apnea pathogenesis. Hypoglossal nerve stimulation activates upper airway dilator muscles, including the genioglossus, and has the potential to reduce obstructive sleep apnea severity. The objective of this study was to examine the safety, feasibility and efficacy of a novel hypoglossal nerve stimulation system (HGNS®; Apnex Medical, St Paul, MN, USA) in treating obstructive sleep apnea at 12 months following implantation. Thirty-one subjects (35% female, age 52.4 ± 9.4 years) with moderate to severe obstructive sleep apnea and unable to tolerate positive airway pressure underwent surgical implantation..
View full abstractGrants
Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
EJK was supported by a career development award from the National Center for Research Resources (NCRR) of the National Institutes of Health and a Triological Society Research Career Development Award of the American Laryngological, Rhinological, and Otological Society. EJK had full access to all the data in the study and had final responsibility for the decision to submit for publication. JW is supported by a NHMRC Practitioner Fellowship No. 632910. ARS is supported by the Heart, Lung and Blood Institute of the National Institutes of Health under grant HL50381. PRE is supported by a National Health & Medical Research Council (Australia) Senior Research Fellowship No. 513704. The authors acknowledge the assistance of Mr Chris Mullin from The Integra Group with the statistical analyses. The authors note with sadness the untimely death of their collaborator Dr Sam Robinson and dedicate this manuscript to him.