Journal article

Low glycaemic index diet reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

Tae Hwan Kim, Steven Petrou, Christopher A Reid

EPILEPSY RESEARCH | ELSEVIER | Published : 2014

Abstract

PURPOSE: Clinical evidence suggests that low glycaemic index diets are effective at reducing seizure frequency potentially through the stabilization of blood glucose levels. Here we investigate if diets containing carbohydrates with varying glycaemic index (GI) can modulate seizure susceptibility in a mouse model of generalized epilepsy. METHODS: Electrocortical recordings were made from mice harboring the GABAAγ2 (R43Q) epilepsy mutation after three weeks on a low-or high-GI diet. Standard rodent diet was used as a control. Occurrence and durations of spike-wave-discharges (SWDs) were measured. An insulin injection was used to reduce blood glucose to levels known to precipitate SWDs in the ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Future Fellowship, Australian Research Council


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council of Australia (grant numbers 400121, 628520 and 631541). CAR was also supported by an Australian Future Fellowship, Australian Research Council (#FT0990628). SP was supported by a NHMRC fellowship. Florey Institute of Neuroscience and Mental Health is supported by Victorian State government infrastructure funds.