Journal article
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations
D Mouradov, E Domingo, P Gibbs, RN Jorissen, S Li, PY Soo, L Lipton, J Desai, HE Danielsen, D Oukrif, M Novelli, C Yau, CC Holmes, IT Jones, S McLaughlin, P Molloy, NJ Hawkins, R Ward, R Midgely, D Kerr Show all
American Journal of Gastroenterology | Published : 2013
DOI: 10.1038/ajg.2013.292
Abstract
OBJECTIVES:Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. However, a substantial group of double-negative (MSI-/CIN-) CRCs exists. The prognosis of these patients is unclear. Furthermore, MSI and CIN are each associated with specific molecular changes, such as mutations in KRAS and BRAF, that have been associated with prognosis. It is not known which of MSI, CIN, and the specific gene mutations are primary predictors of survival.METHODS:We evaluated the prognostic value (disease-free..
View full abstractGrants
Awarded by Medical Research Council
Funding Acknowledgements
Financial support: This work was supported by the Hilton Ludwig Cancer Metastasis Initiative (to O.M.S.), the NHMRC through a Project Grant (Application ID 489418; to L. L., P. M., R. W., O.M.S.), and the Victorian Government through a Victorian Cancer Agency Translation Cancer Research Grant (to P. G., O.M.S.). J.D. is supported by the Victorian Cancer Agency through a Clinical Researcher Fellowship. L. L. is supported by the CSIRO Preventative Health Flagship through a Clinical Researcher Fellowship. Cancer Research UK supported I. T. and the Oxford NIHR Comprehensive Biomedical Research Centre, E. D. The Wellcome Trust Centre for Human Genetics, Oxford is supported by core grant (090532/Z/09/Z). C.Y. is supported by a UK Medical Research Council Specialist Training Fellowship in Biomedical Informatics (Ref. No. G0701810).