Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

AKT regulation of growth and proliferation

Ribosome synthesis and function is critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely,..

Targetting deregulated signalling pathways in high-grade serous ovarian cancer: Defining therapeutic response and mechanisms of resistance

Ovarian cancer is the major cause of death from gynaecological cancer. Most patients present with advanced disease and die of their cancer. ..

Characterisation of a PIK3CA mutation in breast and ovarian cancer

PIK3CA mutations are frequently found in breast and ovarian cancers but how they cause cancer is not clear. We will exploit a unique mouse m..

Research Fellowship

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Anti-cancer activities of HDAC inhibitors

HDAC inhibitors (HDACi) are new chemotherapeutic drugs that kill tumors cells through a cell suicide process called apoptosis. We have now e..

Immune regulation, effector function and therapy

The immune system plays an important role in protecting the host from viral and bacterial infections, and inhibits cancer onset and progress..

Novel regulation of rDNA transcription by mTOR/S6K signalling

Increased cellular growth requires a number of important processes to occur, the most fundamental of which is protein synthesis. Successful ..

Regulation of ribosomal gene transcription by c-MYC during differentiation and lymphomagenesis.

A fundamental question in medical biology revolves around how cells respond to the demands to grow and produce proteins, particularly in the..

Immune regulation, effector function and therapy

The immune system plays an important role in protecting the host from viral and bacterial infections, and inhibits cancer onset and progress..

New therapies for MYC-associated cancers

This proposal will evaluate a new strategy for treating cancers associated with the cancer causing gene MYC. Globally there are more than 1 ..

"Deregulation of ribosome signalling, synthesis and function during malignant transformation."

A major feature of tumour progression is accelerated cell growth and protein synthesis. Moreover, increased synthesis of ribosomes (the prot..