Journal article
Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort
CJ Lodge, S Zaloumis, AJ Lowe, LC Gurrin, MC Matheson, C Axelrad, CM Bennett, DJ Hill, CS Hosking, C Svanes, MJ Abramson, KJ Allen, SC Dharmage
Journal of Pediatrics | Published : 2014
Abstract
Objective To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors. Study design Current wheeze was recorded 23 times up to age 7 years in a birth cohort at high risk for allergy (n = 620). Latent class analysis of wheeze responses identified 5 classes. Multinomial logistic regression estimated associations of probability-weighted wheezing classes with early-life factors. All phenotypes were compared with never/infrequent wheezers. Results Lower respiratory tract infection (LRTI) by 1 year (relative risk [RR], 3.00; 95% CI, 1.58-5.70), childcare by 1 year (RR, 1.51; 95% CI, 1.02-2.22), and higher body mass index (RR, 2.51; 95% CI, 1.09-5.81) were associat..
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Funding Acknowledgements
Funding for the first 6 years of the study was from Nestec (a subsidiary of Nestle Australia). The 12-year follow-up was supported by the Asthma Foundation of Victoria. C.L. is funded by the Sidney Myer Health Fund. C.L.A.L., L.G., M.M., and S.D. are funded by the National Health and Medical Research Council of Australia. K.A. is funded by the Charles and Sylvia Viertel Charitable Foundation. M.A. holds an investigator initiated grant from Pfizer for unrelated research. The other authors declare no conflicts of interest.