Journal article
Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease
TLS Benzinger, T Blazey, CR Jack, RA Koeppe, Y Su, C Xiong, ME Raichle, AZ Snyder, BM Ances, RJ Bateman, NJ Cairns, AM Fagan, A Goate, DS Marcus, PS Aisen, JJ Christensen, L Ercole, RC Hornbeck, AM Farrar, P Aldea Show all
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2013
Abstract
Major imaging biomarkers of Alzheimer's disease include amyloid deposition [imaged with [11C]Pittsburgh compound B (PiB) PET], altered glucose metabolism (imaged with [18F]fluro-deoxyglucose PET), and structural atrophy (imaged by MRI). Recently we published the initial subset of imaging findings for specific regions in a cohort of individuals with autosomal dominant Alzheimer's disease. We now extend this work to include a larger cohort, wholebrain analyses integrating all three imaging modalities, and longitudinal data to examine regional differences in imaging biomarker dynamics. The anatomical distribution of imaging biomarkers is described in relation to estimated years from symptom ons..
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Awarded by National Center for Research Resources
Funding Acknowledgements
We wish to acknowledge the dedication of the participants and their families, without which these studies would not be possible, and all of the participating researchers in the Dominantly Inherited Alzheimer Network (www.dian-info.org/personnel.htm). We also thank Dr. Brian Gordon for his helpful comments on earlier versions of this manuscript. Funding for this research was provided by National Institutes of Health(NIH)/National Institute on Aging (NIA) (U19AG032438). Computations were performed using the facilities of the Washington University Center for High Performance Computing, which were partially provided through National Center for Research Resources (NCRR) 1S10RR022984-01A1. Research reported in this publication was additionally supported by the Charles F. and Joanne Knight Alzheimer's Research Initiative, Alzheimer's Research UK, Brain Research Trust and the Washington University Institute of Clinical and Translational Sciences grant UL1 TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the NIH.