Journal article
Impaired default network functional connectivity in autosomal dominant Alzheimer disease
JP Chhatwal, AP Schultz, K Johnson, TLS Benzinger, C Jack, BM Ances, CA Sullivan, SP Salloway, JM Ringman, RA Koeppe, DS Marcus, P Thompson, AJ Saykin, S Correia, PR Schofield, CC Rowe, NC Fox, AM Brickman, R Mayeux, E McDade Show all
Neurology | Published : 2013
Abstract
Objective: To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin- 2 (PSEN2), and amyloid precursor protein (APP)mutations participating in the Dominantly Inherited Alzheimer Network. Methods: Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families underwent fMRI during resting state at 8 centers in the United States, United Kingdom, and Australia. Using group-independent component analysis, fcMRI was compared using mutation status and Clinical Dementia Rating to stratify groups, and related to each participant's estimated year..
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Awarded by National Institute on Aging
Funding Acknowledgements
Data collection for this project was supported by the Dominantly Inherited Alzheimer Network (DIAN, U19AG032438 to J.C.M.) and data analyses by a K24 grant (AG035007 to R. A. S.), both funded by the National Institute on Aging (NIA).