Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches
Amee J George, Ross D Hannan, Walter G Thomas
FEBS JOURNAL | WILEY | Published : 2013
To influence physiology and pathophysiology, G protein-coupled receptors (GPCRs) have evolved to appropriate additional signalling modalities, such as activation of adjacent membrane receptors. Epidermal growth factor receptors (EGFRs) mediate growth and remodelling actions of GPCRs, although the precise network of gene products and molecular cascades linking GPCRs to EGFRs (termed EGFR transactivation) remains incomplete. In this review, we describe the current view of GPCR-EGFR transactivation, identifying the established models of receptor cross-talk. We consider the limitations in our current knowledge, and propose that recent advances in molecular and cell biology technology, including ..View full abstract
Awarded by Australian National Health and Medical Research Council
This work was supported by project grants awarded to W.G.T and R.D.H. from the Australian National Health and Medical Research Council (grant numbers 472640 and 1024726). R.D.H also holds a National Health and Medical Research Council senior research fellowship.