The nucleolus: an emerging target for cancer therapy
Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan
TRENDS IN MOLECULAR MEDICINE | ELSEVIER SCI LTD | Published : 2013
For over 100 years, pathologists have utilised an increase in size and number of nucleoli, the subnuclear site of ribosome synthesis, as a marker of aggressive tumours. Despite this, the contribution of the nucleolus and ribosomal RNA synthesis to cancer has been largely overlooked. This concept has recently changed with the demonstration that the nucleolus indirectly controls numerous other cellular functions, in particular, the cellular activity of the critical tumour suppressor protein, p53. Moreover, selective inhibition of ribosomal gene transcription in the nucleolus has been shown to be an effective therapeutic strategy to promote cancer-specific activation of p53. This article review..View full abstract
Owing to scope and space limitations, the authors have not been able to individually cite many of the original publications that have contributed substantially to the field. The authors sincerely apologise to the authors of these publications. This work was supported by the National Health and Medical Research Council (NHMRC) of Australia Project Grants, Leukaemia Foundation Grant in Aid, Prostate Cancer Foundation of Australia Grant in Aid, and a NHMRC Research Fellowship to R.D.H.