Journal article
Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum
J Healer, JK Thompson, DT Riglar, DW Wilson, YHC Chiu, K Miura, L Chen, AN Hodder, CA Long, DS Hansen, J Baum, AF Cowman
Plos One | Published : 2013
Abstract
Background:A highly effective vaccine against Plasmodium falciparum malaria should induce potent, strain transcending immunity that broadly protects against the diverse population of parasites circulating globally. We aimed to identify vaccine candidates that fulfill the criteria.Methods:We have measured growth inhibitory activity of antibodies raised to a range of antigens to identify those that can efficiently block merozoite invasion for geographically diverse strains of P. falciparum.Results:This has shown that the conserved Region III-V, of the P. falciparum erythrocyte-binding antigen (EBA)-175 was able to induce antibodies that potently inhibit merozoite invasion across diverse parasi..
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Grants
Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council of Australia by a Program grant (637406) and a project grant (1011453). This work was also supported through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. AFC is a Howard Hughes International Scholar (55007645). This work was also supported by grants from the Bill and Melinda Gates Foundation, PATH/MVI, and USAID. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.