Journal article
Identification of a novel PNMA-MS1 gene in marsupials suggests the LTR retrotransposon-derived PNMA genes evolved differently in marsupials and eutherians
S Iwasaki, S Suzuki, M Pelekanos, H Clark, R Ono, G Shaw, MB Renfree, T Kaneko-Ishino, F Ishino
DNA Research | OXFORD UNIV PRESS | Published : 2013
Abstract
Two major gene families derived from Ty3/Gypsy long terminal repeat (LTR) retrotransposons were recently identified in mammals. The sushi-ichi retrotransposon homologue (SIRH) family comprises 12 genes: 11 in eutherians including Peg10 and Peg11/Rtl1 that have essential roles in the eutherian placenta and 1 that is marsupial specific. Fifteen and 12 genes were reported in the second gene family, para-neoplastic antigen MA (PNMA), in humans and mice, respectively, although their biological functions and evolutionary history remain largely unknown. Here, we identified two novel candidate PNMA genes, PNMA-MS1 and -MS2 in marsupials. Like all eutherian-specific PNMA genes, they exhibit the highe..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
This work was supported by grants from the Australian Research Council Centre of Excellence in Kangaroo Genomics to M.B.R., Japan Society for the Promotion of Science (JSPS), Bilateral Program on Joint Research Project to F.I. and T.K-I. and Funding Program for Next Generation World-Leading Researchers (NEXT Program) to T.K-I., the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, Grants-in-Aid for Scientific Research (S) and the Global Center for Excellence (GCOE) Program for International Research Center for Molecular Science in Tooth and Bone Diseases and Medical Research Institute, Tokyo Medical and Dental University, Joint Usage/Research Program to F.I.