Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Morgan D Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M O'Neill, Rebecca J Ford, Rengasamy Palanivel, Matthew O'Brien, D Grahame Hardie, S Lance Macaulay, Jonathan D Schertzer, Jason RB Dyck, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg
Nature Medicine | NATURE PUBLISHING GROUP | Published : 2013
We thank C. Saab from the McMaster Centre for Translational Imaging for completing the computed tomography analysis and S. Stypa and E. Day for technical assistance. This study was supported by grants and fellowships from the Australian Research Council and the Commonwealth Scientific and Industrial Research Organisation (B.E.K.), the Australian National Health and Medical Research Council (B.E.K., B.J.v.D. and G.R.S.), the Canadian Diabetes Association (G.R.S., J.R.B.D. and J.D.S.) and the Canadian Institutes of Health Research (CIHR) (G.R.S. and J.R.B.D.) and was supported in part by the Victorian Government Operational Infrastructure Support Program (B.E.K.) and the Canadian Foundation for Innovation (G.R.S.). M.D.F. is supported by a CIHR Banting Postdoctoral Fellowship, J.D.S. is supported by a Canadian Diabetes Association Scholar Award and G.R.S. holds a Canada Research Chair in Metabolism and Obesity.