Journal article

Preventing breast and ovarian cancers in high-risk BRCA1 and BRCA2 mutation carriers

Ian M Collins, Roger L Milne, Prue C Weideman, Sue-Anne McLachlan, Michael L Friedlander, Kathleen Cuningham, John L Hopper, Kelly-Anne Phillips

MEDICAL JOURNAL OF AUSTRALIA | AUSTRALASIAN MED PUBL CO LTD | Published : 2013

Abstract

OBJECTIVE: To estimate the prevalence of the use of cancer risk-reducing measures among Australian BRCA1 and BRCA2 mutation carriers. DESIGN, SETTING AND PARTICIPANTS: Prospective follow-up of female carriers of BRCA1 or BRCA2 mutations who had no personal history of cancer and were enrolled in a multiple-case breast cancer family cohort study (kConFab). Data, including cancer events and uptake of risk-reducing surgery and medication were collected by self-report at cohort entry and 3 yearly thereafter. Surgery was confirmed from pathology and medical records. Women were followed up from enrolment until cancer diagnosis, date of last follow-up, or death. Data were collected from 3 November 1..

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Grants

Awarded by National Breast Cancer Foundation Priority Driven Collaborative Cancer Research Scheme in conjunction with the National Health and Medical Research Foundation


Awarded by National Breast Cancer Foundation


Funding Acknowledgements

This work was specifically supported by the 2009 Cancer Australia and the National Breast Cancer Foundation Priority Driven Collaborative Cancer Research Scheme in conjunction with the National Health and Medical Research Foundation (628333). kConFab is supported by grants from the National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC) and by the Queensland Cancer Fund. the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia. and the Cancer Foundation of Western Australia. Kelly-Anne Phillips is supported by a National Breast Cancer Foundation Practitioner Fellowship. John Hopper is an NHMRC Senior Principal Research Fellow. We thank Lucy Stanhope, Rachel Waller and Sophie Walker for data collection. We also thank Heather Thorne, Eve line Niedermayr, the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics and the many families enrolled in kConFab for their contributions to this resource.