Journal article

Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer

Linda T Hiraki, Conghui Qu, Carolyn M Hutter, John A Baron, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Bette J Caan, Graham Casey, Jenny Chang-Claude, Stephen J Chanock, David V Conti, David Duggan, Charles S Fuchs, Steven Gallinger, Edward L Giovannucci, Tabitha A Harrison, Richard B Hayes, Aditi Hazra, Brian Henderson Show all

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2013

Grants

Awarded by National Cancer Institute, NIH under RFA


Awarded by Australasian Colorectal Cancer Family Registry


Awarded by Seattle Colorectal Cancer Family Registry


Awarded by Ontario Registry for Studies of Familial Colorectal Cancer


Awarded by NIH


Awarded by National Cancer Institute


Awarded by German Research Council (Deutsche Forschungsgemeinschaft)


Awarded by German Federal Ministry of Education and Research


Awarded by National Cancer Institute, NIH, U. S. Department of Health and Human Services


Awarded by National Cancer Institute, NIH, U.S. Department of Health and Human Services


Awarded by NIH, Genes, Environment and Health Initiative [NIH GEI]


Awarded by NIH GEI


Awarded by NIH from the National Cancer Institute


Awarded by National Heart, Lung, and Blood Institute, NIH, U.S. Department of Health and Human Services



Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

S. Bezieau and S. Kury are affiliated with ASTERISK which was funded by a regional Programme Hospitalier de Recherche Clinique (PHRC) and supported by the Regional Council of Pays de la Loire, the Groupement des Entreprises Francaises dans la Lutte contre le Cancer (GEFLUC), the Association Anne de Bretagne Genetique, and the Ligue Regionale Contre le Cancer (LRCC).J.A. Baron, G. Casey, D.V. Conti, J.L. Hopper, M. A. Jenkins, P. A. Newcomb, and F.R. Schumacher are affiliated with CCFR which is supported by the National Cancer Institute, NIH under RFA # CA-95-011 and through cooperative agreements with members of the CCFR and principal investigators (P.I.s). This genome wide scan was supported by the National Cancer Institute, NIH by U01 CA122839. The content of this article does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government or the CFR. The following CCFR centers contributed data to this article and were supported by the following sources: Australasian Colorectal Cancer Family Registry (U01 CA097735), Seattle Colorectal Cancer Family Registry (U01 CA074794), and Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783).S. Gallinger, T.J. Hudson, M. Lemire, and B.W. Zanke are affiliated with OFCCR which is supported by the NIH, through funding allocated to the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); see CCFR section above. As subset of ARCTIC, OFCCR is supported by a GL2 grant from the Ontario Research Fund, the Canadian Institutes of Health Research, and the Cancer Risk Evaluation (CaRE) Program grant from the Canadian Cancer Society Research Institute. T.J. Hudson and B. W. Zanke are recipients of Senior Investigator Awards from the Ontario Institute for Cancer Research, through generous support from the Ontario Ministry of Research and Innovation.B. Henderson and L. Le Marchand are affiliated with COLO2&3/MEC. COLO2&3 is supported by the National Cancer Institute (R01 CA60987). MEC is supported by R37 CA54281, P01 CA033619, and R01 CA63464.H. Brenner, J. Chang-Claude, and M. Hoffmeister are affiliated with DACHS which was supported by grants from the German Research Council (Deutsche Forschungsgemeinschaft, BR 1704/6-1, BR 1704/6-3, BR 1704/6-4, and CH 117/1-1), and the German Federal Ministry of Education and Research (01KH0404 and 01ER0814).B.J. Caan, J.D. Potter, and M.L. Slattery are affiliated with DALS which was supported by the National Cancer Institute, NIH, U. S. Department of Health and Human Services (R01 CA48998 to M. L. Slattery).T.A. Harrison, C.M. Hutter, U. Peters, and C. Qu are affiliated with GECCO which is supported by National Cancer Institute, NIH, U.S. Department of Health and Human Services (U01 CA137088). Funding for the genome-wide scan of DALS, PLCO, and WHI was provided by the National Cancer Institute, NIH, U. S. Department of Health and Human Services (R01 CA059045).A.T. Chan, C.S. Fuchs, E.L. Giovannucci, L.T. Hiraki, A. Hazra, P. Kraft, H. Nan, K. Ng, and K. Wu are affiliated with HPFS, NHS, and PHS. HPFS was supported by the NIH (P01 CA 055075, UM1 CA167552, R01 137178, and P50CA127003), NHS by the NIH (R01 137178, P50CA127003, and P01 CA087969) and PHS by the NIH (CA42182). A.T. Chan is a Damon Runyon Clinical Investigator and also supported by K24 DK098311. L.T. Hiraki was supported by a Canadian Institute of Health Research (CIHR) Fellowship Award.S.I. Berndt, S.J. Chanock, R.B. Hayes, and R.E. Schoen are affiliated with PLCO which was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and supported by contracts from the Division of Cancer Prevention, National Cancer Institute, NIH, DHHS. Control samples were genotyped as part of the Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer scan, supported by the Intramural Research Program of the National Cancer Institute. The datasets used in this analysis were accessed with appropriate approval through the dbGaP online resource (http://www.cgems.cancer.gov/data_acess.html) through dbGaP accession number 000207v.1p1.c1. [National Cancer Institute (2009) CGEMS data website. http://cgems.cancer.gov/data_access.html; ref. 75]. Control samples were also genotyped as part of the GWAS of Lung Cancer and Smoking [76]. Funding for this work was provided through the NIH, Genes, Environment and Health Initiative [NIH GEI] (Z01 CP 010200). The human subjects participating in the GWAS are derived from the Prostate, Lung, Colon and Ovarian Screening Trial and the study is supported by intramural resources of the National Cancer Institute. Assistance with genotype cleaning, as well as with general study coordination, was provided by the Gene Environment Association Studies, GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the National Center for Biotechnology Information. Funding support for genotyping, which was conducted at the Center for Inherited Disease Research, Johns Hopkins University (Baltimore, MD) was provided by the NIH GEI (U01 HG 004438). The datasets used for the analyses described in this article were obtained from dbGaP at http://www.ncbi.nlm.nih.gov/gap through dbGaP accession number phs000093.E. White is affiliated with VITAL which is supported in part by the NIH (K05 CA154337) from the National Cancer Institute and Office of Dietary Supplements.J. Manson and J. Wactawski-Wende are affiliated with WHI. The WHI program is funded by the National Heart, Lung, and Blood Institute, NIH, U.S. Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C.